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This page is designed for the three hour ,
eleven meg. MP3 audio file included in download
excellent typed summary , 60 pages , by Linda Sleffel , @
New Insights into the
Pathophysiology and Treatment of CFS
Paul Cheney, M.D.,Ph.D.
October 2001
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Neuropsychiatric Phenomena Cognitive Disturbances - 99% of cases Processing Speed |
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Neuropsychiatric Phenomena Mood Disturbances - 60% of cases Depression - rarely severe |
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The Dysfunction of CFS Symptom Dysfunction - The misery Component Dynamic Dysfunction - The Action Component |
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The Evolution of CFS Phase One - The Onset or Trigger Phase Phase Two - The Triad Phase Phase Three - The Dynamic Injury Phase |
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The Key Scientific Literature Phase
One -- Suhadolnik et al (Temple U. - USA) Phase Two -- McGregor et al
(Newcastle U. - NSW) Phase Three -- Demitrack et al (NIH -
USA) |
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The Physical Exam Immune Activation Lymphodynia (PCN,SCN) - 80% - 90% |
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The Physical Exam Sub- cortical Brain Injury Vestibular Dysfunction -- 94% |
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The Physical Exam Metabolic Disturbances Shortened Breath-holding - 70% |
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Oxygen Transport Blood Acid-Base Status (Alkaline Inhibits) Red Cell 2-3 DPG Status (Lower Inhibits) Mitochondrial Function Micro-circulation |
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Mitochondrial Function R-Nase-L
Activity (Inappropriate) RNase-L Activity (Appropriate) Xenobiotic Poisoning Heavy Metals (especially Mercury) Growth Hormone Deficiency DNA Gene Re-arrangements or Alterations in Normal Expression |
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Magnetic Resonance Spectroscopy N-20 70% of patients show elevated lactate levels in the thalamus and surrounding structures 10% of patients show reduced NAA peak and elevated Choline peak, also in the thalamus and surrounding structures Recent study out of the University of Liverpool shows similar findings in the hippocampus of CFS patients |
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The Key Scientific Literature Step I
-- Holmes et al (CDC - USA) Step II -- Zivin et al (Scientific
American - USA) Step III -- Bland et al (Healthcom Inc. - USA) Step IV -- Beck et al (NEJM - USA) |
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The Key Scientific Literature Step V
-- Pimental et al (UCLA - USA) Step VI -- Bland et al (Healthcom Inc. - USA) Step VII -- Bennett et al (U. Oregon
- USA) Misc. -- Carter et al (Hemispherex
Inc - USA) |
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Treatment Overview Phase I -- High RNase-L Activity / TH2 Activation / with or without coagulopathy Ampligen Anti-microbial Therapy Immune Modulation @ Anticoagulant Therapy |
| Paul Cheney is no longer
using Commonwealth Biotechnologies TAQMAN
Assay at all. (It did a
quantitative measure of the usual viruses.) Cheney now uses Medical Diagnostic Laboratories - the ultimate bug lab, he calls it. It is fully licensed, unlike Commonwealth, which is not a commercially licensed lab at all - it's a biotech company. Cheney uses Medical Diagnostic Labs CFS Panel - it tests for EBV, CMV, HHV 6a, HHV 6b, HHV 8, Herpes Simplex, several strains of Mycoplasma, and several strains of Chlamydia. He will also on occasion use their mycology panel. Candida, aspergillus, others molds/fungus, etc. He trusts all their tests, including Lyme. www.mdlab.com 1-877-269-0090 This info is as of Nov 26, 2002. Carol S |
| Paul Cheney is now using
Medical Diagnostics Lab to test for all the herpes virsus
(CMB, EBV, HHV 6a, HHV 6b, HHV 8), the Mycoplasmas and
Chlamydias. It's quantitative and is called,
appropriately, the CFS Panel.@ Any doctor can order
a test kit to be sent to you and draw the blood. The lab
files with most insurance. One immune panel that Cheney uses is the Molecular Biology of CFIDS, offered by Immunosciences Laboratory. @ It tests the regular RNase L, NK function, Alpha Interferon, 2-5A Synthetase, Apoptosis, Fas (CD95), Protein Kinase RNA. The website contains good info on these as well. Any of the above are available individually, as well as part of the whole panel. Carol S 11-03-2002 |
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Treatment Overview Phase II --Xenobiotic Toxicity Source
Attenuation High Dose Hydroxycobalamin |
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Treatment Overview Phase III - CNS Injury / DNA Damage Growth
Hormone Stimulation Fetal Bovine Growth Factors - limited |
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Initial Treatment Principles Integrated Program (no one element suffices) |
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Treatment - Step 1 Lifestyle Adjustments
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Treatment - Step I General Metabolic Support Blood Volume - Adaptogenic Expansion Gookinaid @ ERG / Isotonic Home Recipe Oxygen Transport Autonomic Nervous System Regulation |
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Treatment - Step I Other paths to Advance Self Healing Autonomic Balance / Stress Reduction Conscious Beliefs and Attitudes (CBT / Siegel) The Unconcious Wound (Imago Therapy) The Transpersonal Self (Spiritual) |
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Treatment - Step II Neuroprotection via Threshold Potentials NMDA
Blockers GABA Agonists |
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Treatment Step III DNA Protection Antioxidant Vitamins Bioflavinoids Extra Vitamin E Special Supplements CoQ-10 (fat soluble) Lipoic Acid (physiologic) Omega-3 and Omega-6 Essential Oils Melatonin (if needed) |
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Treatment - Step IV Neuroprotection from CNS Toxicity CNS Xenobiotic Detoxification Parenteral Hydroxycobalamin Starting at 10,000 mcg IM HS
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Treatment - Step V Toxic Source Attenuation GI Tract - Microbial Toxicity Source Olive Leaf Extract S. Boulardii (limit) Organic Botanical Extracts (limit) Glutamine Source Polymicrobial Probiotic without FOS Oral Cavity - Microbial Toxicity Source Herbal Tooth and Gum Tonic Remove or detoxify RCT and Cavitations |
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Treatment - Step V Toxic Source Attenuation Heavy Metals (Load and Toxic Potential) Amalgams - Be very careful of Removing Fish Water Supply Home Environment Home Mold Plate Testing Air Duct Inspections and Cleaning Electronic Air Duct Inserts - Mold HEPA / HEGA Air Filters Personal VOC Badges (3M) CO Detectors |
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Treatment - Step VI Detoxification - Beware of Toxic Mobilization Hydroxycobalamin (start at 10,000 mcg / day) Methylsulfonylmethane (MSM at 6-12 g / day) Whey Protein Concentrate (10-20 g / day) @ Guaifenesin (short acting - start at 300 mg Q12h) @ Growth Hormone (0.2 mg SQ MiniQuick Q- week) |
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Treatment - Step VI Novel Forms of Detoxification Colon Hydrotherapy (Should be Time Limited) Hydrogen Peroxide / Epsom Salts Bathing (BIW) infrared Light Pads Over Lymphatic Drainage Sites 2-40 minutes TIW (Activates NOS3) Deep Tissue Massage BIW Infrared Sauna at Low temperatures TIW |
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Treatment - Step VII Enhancing the Phase III Recovery Trajectory Growth Hormone Injections (QW-BIW) Fetal Bovine Growth Factors (BIW-Limited) Mesenchyme and liver, thymus, Adrenal, Brain |
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Growth Hormone / Growth Factor Study Preliminary Results Nine have completed or are poised to complete the study 6 of 9 or 67% are responders (good to excellent) Three are either on hold or are very early in the study - too early to tell |
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Growth Hormone / Growth Factor Study Preliminary Results Growth hormone must be kept at low doses given once or twice weekly Patients must be immune modulated before starting GH or GF Growth factor dose needs to be adjusted downward similar to GH |
Question answer session - 30 minutes
| Carol Sieverling CFSFMExperimental Cheney video still available 03-18-2002 The Cheney video from his October 2001 seminar will be available for some time to come. We're on our third order from the production company! In the US: $15 check made out to the CFS/FM Support Group of DFW and mailed to 513 Janann St, Euless TX 76039. A phone number on the check or giving us your email address could prove useful if there are problems or questions. Outside the US: $20 in cash or a check drawn on a American bank. (Sorry, other forms of payment involve significant collection fees for us.) To my knowledge, the cash has always arrived safely. Mail to same address - and please be sure your equipment is compatible with North American videos. The videos should be available for quite sometime. We can reorder them indefinitely from the production company. Carol Sieverling site mail |
My (Bob Joy) guai-whey website @
This page is designed for the three hour ,
eleven meg. MP3 audio file
